Naotomo Kambe Selected Research

Blau syndrome

1/2022	Potential Benefits of TNF Targeting Therapy in Blau Syndrome, a NOD2-Associated Systemic Autoinflammatory Granulomatosis.
1/2022	Anti-TNF treatment corrects IFN-γ-dependent proinflammatory signatures in Blau syndrome patient-derived macrophages.
1/2021	Sustained Surface ICAM-1 Expression and Transient PDGF-B Production by Phorbol Myristate Acetate-Activated THP-1 Cells Harboring Blau Syndrome-Associated NOD2 Mutations.
10/2020	Blau Syndrome: NOD2-related systemic autoinflammatory granulomatosis.
1/2018	Pluripotent stem cell models of Blau syndrome reveal an IFN-γ-dependent inflammatory response in macrophages.
1/2009	Role of the NOD2 genotype in the clinical phenotype of Blau syndrome and early-onset sarcoidosis.
2/2005	Early-onset sarcoidosis and CARD15 mutations with constitutive nuclear factor-kappaB activation: common genetic etiology with Blau syndrome.

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Naotomo Kambe Research Topics

Disease

9	Cryopyrin-Associated Periodic Syndromes 11/2021 - 11/2005
7	Blau syndrome 01/2022 - 02/2005
5	Exanthema (Rash) 11/2021 - 05/2009
5	Inflammation (Inflammations) 01/2021 - 03/2008
4	Urticaria (Hives) 01/2022 - 05/2009
4	Pruritus (Itching) 01/2022 - 01/2008
3	Contact Dermatitis (Eczema, Contact) 01/2022 - 06/2010
2	Hypersensitivity (Allergy) 01/2022 - 12/2006
2	Fever (Fevers) 11/2021 - 03/2008
2	Pain (Aches) 11/2021 - 03/2008
2	Hyperplasia 01/2021 - 10/2015
2	Atopic Dermatitis (Atopic Eczema) 01/2021 - 01/2008
2	Granuloma 01/2021 - 08/2005
2	Hereditary leiomyomatosis and renal cell cancer 12/2020 - 01/2013
2	Psoriasis (Pustulosis Palmaris et Plantaris) 06/2019 - 05/2018
2	Sarcoidosis (Schaumann Disease) 10/2018 - 07/2017
2	Necrosis 02/2008 - 04/2007
1	Schnitzler Syndrome 11/2021
1	Leukocytosis (Pleocytosis) 11/2021
1	Neoplasms (Cancer) 02/2021
1	Chronic Urticaria 07/2019
1	Disease Progression 07/2019
1	BCR-ABL Positive Chronic Myelogenous Leukemia (Chronic Myelogenous Leukemia) 01/2019
1	Exfoliative Dermatitis (Erythroderma) 01/2019
1	Sweet Syndrome (Acute Febrile Neutrophilic Dermatosis) 01/2019
1	Pityriasis Rubra Pilaris 01/2019
1	Lung Diseases (Lung Disease) 07/2017
1	Myositis (Idiopathic Inflammatory Myopathies) 10/2015
1	Infections 01/2015
1	Polyarteritis Nodosa (Periarteritis Nodosa) 01/2015
1	Fibrosis (Cirrhosis) 11/2013
1	Crohn Disease (Crohn's Disease) 04/2013
1	Skin Diseases (Skin Disease) 07/2012
1	Hypotrichosis 09/2011
1	Skin Manifestations 06/2010
1	Dermatitis 06/2010
1	Mastocytosis 03/2010
1	Chemical Burns (Chemical Burn) 11/2008
1	Myocardial Infarction 03/2008
1	Exercise-Induced Allergies 03/2008

Drug/Important Bio-Agent (IBA)

7	NucleotidesIBA 01/2022 - 05/2009
5	NF-kappa B (NF-kB)IBA 04/2013 - 02/2005
4	CytokinesIBA 01/2022 - 06/2010
4	InflammasomesIBA 01/2019 - 05/2009
3	Histamine (Histamine Dihydrochloride)FDA Link 01/2022 - 01/2008
3	InterleukinsIBA 11/2021 - 05/2009
3	LigandsIBA 01/2021 - 01/2009
2	Histamine Antagonists (Antihistamines)IBA 01/2022 - 01/2008
2	Immunoglobulin E (IgE)IBA 01/2022 - 12/2006
2	Omalizumab (Xolair)FDA Link 01/2022 - 07/2019
2	Immunoglobulins (Immunoglobulin)IBA 11/2021 - 07/2002
2	Fumarate Hydratase (Fumarase)IBA 12/2020 - 01/2013
2	Muramidase (Lysozyme)IBA 10/2018 - 07/2017
2	Interleukin-2 Receptors (IL 2 Receptor)IBA 10/2018 - 07/2017
2	Peptidyl-Dipeptidase A (Angiotensin Converting Enzyme)IBA 10/2018 - 07/2017
2	Proteins (Proteins, Gene)FDA Link 10/2017 - 07/2002
2	Leucine (L-Leucine)FDA Link 06/2010 - 05/2009
1	Surface-Active Agents (Surfactants)IBA 01/2022
1	Irritants (Vesicants)IBA 01/2022
1	SteroidsIBA 01/2022
1	IgE Receptors (Fc epsilon RI)IBA 01/2022
1	Janus Kinase InhibitorsIBA 01/2022
1	canakinumab FDA Link 11/2021
1	Interleukin 1 Receptor Antagonist Protein (Anakinra)FDA Link 11/2021
1	C-Reactive ProteinIBA 11/2021
1	Immunoglobulin M (IgM)IBA 11/2021
1	tocilizumab (atlizumab)FDA Link 11/2021
1	Adrenal Cortex Hormones (Corticosteroids)IBA 02/2021
1	delgocitinibIBA 01/2021
1	crisaboroleIBA 01/2021
1	dupilumabIBA 01/2021
1	Tetradecanoylphorbol AcetateIBA 01/2021
1	Interleukin-4 (Interleukin 4)IBA 01/2021
1	Interleukin-13IBA 01/2021
1	Intercellular Adhesion Molecule-1 (Intercellular Adhesion Molecule 1)IBA 01/2021
1	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 10/2020
1	AntibodiesIBA 03/2020
1	AntigensIBA 03/2020
1	Peptides (Polypeptides)IBA 06/2019
1	Imiquimod (Aldara)FDA LinkGeneric 06/2019
1	Nerve Growth Factor (NGF)IBA 06/2019
1	Dasatinib (BMS 354825)FDA Link 01/2019
1	Interleukin-17 (Interleukin 17)IBA 01/2019
1	Interleukin-12 (IL 12)IBA 01/2019
1	Antigen-Antibody Complex (Immune Complex)IBA 05/2018
1	Tuberculin (PPD)IBA 07/2017
1	Secretory Phospholipases A2IBA 10/2015
1	NivolumabIBA 10/2015
1	Bleomycin (Blenoxane)FDA LinkGeneric 11/2013
1	Pharmaceutical PreparationsIBA 08/2012
1	Pyrin Domain-Containing 3 Protein NLR FamilyIBA 07/2012
1	Lipase (Acid Lipase)FDA Link 09/2011
1	Interleukin-1 (Interleukin 1)IBA 09/2010
1	Interleukin-18 (Interleukin 18)IBA 06/2010
1	Codon (Codons)IBA 03/2010
1	glycidyl methacrylateIBA 11/2008
1	Aspirin (Acetylsalicylic Acid)FDA LinkGeneric 03/2008
1	LipopolysaccharidesIBA 02/2008

Therapy/Procedure

9	Therapeutics 01/2022 - 03/2008
1	Tonsillectomy 01/2015